Vitamin-D-resistant Osteomalacia

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Hypophosphatemic vitamin D-resistant osteomalacia: A case report

This study concerns the case of a 59-year-old woman who was admitted to hospital after experiencing systemic bone pain and muscle weakness for more than 2 years. The patient was diagnosed with numerous fractures via bone imaging emission computed tomography (ECT) and hypophosphatemia. Laboratory results showed a high alkaline phosphatase concentration. Thyroid nodules were visible on the thyroi...

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Vitamin D Deficiency including Osteomalacia and Rickets

Adequate vitamin D3 by synthesis in the skin and from dietary and supplemental sources is essential for bone health throughout life. [1] Rickets in children and osteomalacia in adults are the classic but extreme manifestations of severe vitamin D deficiency. Links have also been shown between poor vitamin D status and breast cancer, bowel cancer, prostate cancer, lung cancer, metabolic syndrome...

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Vitamin D-resistant diseases.

Hereditary vitamin D receptor defects (HVDRDs) is a more appropriate and precise title for an inborn error of metabolism commonly known as pseudo-vitamin D deficiency or vitamin D dependency, type II. It is a rare autosomal recessive disorder, approximately 70 kindreds were described, but its main importance is elucidating the physiology of vitamin D and calcium homeostasis in humans. Patients ...

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Osteomalacia as a result of vitamin D deficiency.

Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cured by vitamin D replacement, and furthermore, not all individuals with vitamin D deficiency develop osteomalacia. Although in the past osteomalacia was common...

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Treatment of vitamin D deficient osteomalacia may unmask autonomous hyperparathyroidism.

Two cases of vitamin D deficient osteomalacia with secondary hyperparathyroidism are presented. In both cases treatment with vitamin D replacement therapy resulted in elevated calcium levels and a failure of parathormone levels to normalise, indicating autonomous parathyroid activity. Subsequent surgery in one case resulted in removal of a parathyroid adenoma. The importance of osteomalacia and...

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ژورنال

عنوان ژورنال: BMJ

سال: 1958

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.1.5082.1269